AustralieFrV1, Main, Exploration, bibRecord, 005F16

A genome-wide association meta-analysis identifies new childhood obesity loci

Identifieur interne : 005F16 ( Main/Exploration ); précédent : 005F15; suivant : 005F17

A genome-wide association meta-analysis identifies new childhood obesity loci

Auteurs : Jonathan P. Bradfield [États-Unis] ; H. Rob Taal [Pays-Bas] ; Nicholas J. Timpson [Royaume-Uni] ; Andre Scherag [Allemagne] ; Cecile Lecoeur [France] ; Nicole M. Warrington [Australie] ; Elina Hypponen [Royaume-Uni] ; Claus Hoist [Danemark] ; Beatriz Valcarcel [Royaume-Uni] ; Elisabeth Thiering [Allemagne] ; Rany M. Salem [États-Unis] ; Fredrick R. Schumacher ; Diana L. Cousminer ; Patrick M. A. Sleiman [États-Unis] ; JIANHUA ZHAO ; Robert I. Berkowitz ; Karani S. Vimaleswaran [Royaume-Uni] ; Ivonne Jarick ; Craig E. Pennell [Australie] ; David M. Evans [Royaume-Uni] ; Beate St Pourcain [Royaume-Uni] ; Diane J. Berry [Royaume-Uni] ; Dennis O. Mook-Kanamori [Pays-Bas] ; Albert Hofman [Pays-Bas] ; Fernando Rivadeneira [Pays-Bas] ; Andre G. Uitterlinden [Pays-Bas] ; Cornelia M. Van Duijn [Pays-Bas] ; Ralf J. P. Van Der Valk [Pays-Bas] ; Johan C. De Jongste [Pays-Bas] ; Dirkje S. Postma ; Dorret I. Boomsma ; W. James Gauderman ; Mohamed T. Hassanein ; Cecilia M. Lindgren [Pays-Bas] ; Reedik M Gi ; Colin A. G. Boreham ; Charlotte E. Neville ; Luis A. Moreno ; Paul Elliott [Royaume-Uni] ; Anneli Pouta ; Anna-Liisa Hartikainen ; MINGYAO LI ; Olli Raitakari ; Terho Lehtim Ki ; Johan G. Eriksson ; Aarno Palotie ; Jean Dallongeville ; Shikta Das [Royaume-Uni] ; Panos Deloukas ; George Mcmahon ; Susan M. Ring ; John P. Kemp [Royaume-Uni] ; Jessica L. Buxton ; Alexandra I. F. Blakemore ; Mariona Bustamante ; Monica Guxens ; Joel N. Hirschhorn [États-Unis] ; Matthew W. Gillman ; Eskil Kreiner-Moller ; Hans Bisgaard

Source :

Nature genetics [ 1061-4036 ] ; 2012.

RBID : Pascal:12-0235785

Descripteurs français

Pascal (Inist)
- Association, Métaanalyse, Identification, Locus, Etat nutritionnel, Obésité, Echelle du génome.
Wicri :
- topic : Association.

English descriptors

KwdEn :
- Association, Identification, Locus, Metaanalysis, Nutritional status, Obesity.

Abstract

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10-⁶ in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10-⁹; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10^-9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI¹.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370100

Affiliations:

Le document en format XML

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<author><name sortKey="Duijn, Cornelia M Van" sort="Duijn, Cornelia M Van" uniqKey="Duijn C" first="Cornelia M. Van" last="Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Valk, Ralf J P" sort="Van Der Valk, Ralf J P" uniqKey="Van Der Valk R" first="Ralf J. P." last="Van Der Valk">Ralf J. P. Van Der Valk</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Jongste, Johan C" sort="De Jongste, Johan C" uniqKey="De Jongste J" first="Johan C." last="De Jongste">Johan C. De Jongste</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name>
</author>
<author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name>
</author>
<author><name sortKey="Gauderman, W James" sort="Gauderman, W James" uniqKey="Gauderman W" first="W. James" last="Gauderman">W. James Gauderman</name>
</author>
<author><name sortKey="Hassanein, Mohamed T" sort="Hassanein, Mohamed T" uniqKey="Hassanein M" first="Mohamed T." last="Hassanein">Mohamed T. Hassanein</name>
</author>
<author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name>
</author>
<author><name sortKey="Boreham, Colin A G" sort="Boreham, Colin A G" uniqKey="Boreham C" first="Colin A. G." last="Boreham">Colin A. G. Boreham</name>
</author>
<author><name sortKey="Neville, Charlotte E" sort="Neville, Charlotte E" uniqKey="Neville C" first="Charlotte E." last="Neville">Charlotte E. Neville</name>
</author>
<author><name sortKey="Moreno, Luis A" sort="Moreno, Luis A" uniqKey="Moreno L" first="Luis A." last="Moreno">Luis A. Moreno</name>
</author>
<author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>48 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name>
</author>
<author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name>
</author>
<author><name sortKey="Mingyao Li" sort="Mingyao Li" uniqKey="Mingyao Li" last="Mingyao Li">MINGYAO LI</name>
</author>
<author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name>
</author>
<author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name>
</author>
<author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
</author>
<author><name sortKey="Dallongeville, Jean" sort="Dallongeville, Jean" uniqKey="Dallongeville J" first="Jean" last="Dallongeville">Jean Dallongeville</name>
</author>
<author><name sortKey="Das, Shikta" sort="Das, Shikta" uniqKey="Das S" first="Shikta" last="Das">Shikta Das</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>48 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name>
</author>
<author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name>
</author>
<author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name>
</author>
<author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L." last="Buxton">Jessica L. Buxton</name>
</author>
<author><name sortKey="Blakemore, Alexandra I F" sort="Blakemore, Alexandra I F" uniqKey="Blakemore A" first="Alexandra I. F." last="Blakemore">Alexandra I. F. Blakemore</name>
</author>
<author><name sortKey="Bustamante, Mariona" sort="Bustamante, Mariona" uniqKey="Bustamante M" first="Mariona" last="Bustamante">Mariona Bustamante</name>
</author>
<author><name sortKey="Guxens, Monica" sort="Guxens, Monica" uniqKey="Guxens M" first="Monica" last="Guxens">Monica Guxens</name>
</author>
<author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Division of Genetics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Division of Endocrinology, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Program in Genomics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Metabolism Program, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gillman, Matthew W" sort="Gillman, Matthew W" uniqKey="Gillman M" first="Matthew W." last="Gillman">Matthew W. Gillman</name>
</author>
<author><name sortKey="Kreiner Moller, Eskil" sort="Kreiner Moller, Eskil" uniqKey="Kreiner Moller E" first="Eskil" last="Kreiner-Moller">Eskil Kreiner-Moller</name>
</author>
<author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0235785</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0235785 INIST</idno>
<idno type="RBID">Pascal:12-0235785</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001347</idno>
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<idno type="wicri:Area/PascalFrancis/Checkpoint">001413</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001413</idno>
<idno type="wicri:doubleKey">1061-4036:2012:Bradfield J:a:genome:wide</idno>
<idno type="wicri:Area/Main/Merge">006248</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370100</idno>
<idno type="RBID">PMC:3370100</idno>
<idno type="wicri:Area/Pmc/Corpus">002E12</idno>
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<idno type="wicri:Area/Pmc/Checkpoint">002082</idno>
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<idno type="wicri:Area/Ncbi/Merge">000D71</idno>
<idno type="wicri:Area/Ncbi/Curation">000D71</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000D71</idno>
<idno type="wicri:doubleKey">1061-4036:2012:Bradfield J:a:genome:wide</idno>
<idno type="wicri:Area/Main/Merge">005754</idno>
<idno type="wicri:Area/Main/Curation">005F16</idno>
<idno type="wicri:Area/Main/Exploration">005F16</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A genome-wide association meta-analysis identifies new childhood obesity loci</title>
<author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P." last="Bradfield">Jonathan P. Bradfield</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rob Taal, H" sort="Rob Taal, H" uniqKey="Rob Taal H" first="H." last="Rob Taal">H. Rob Taal</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Pediatrics, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scherag, Andre" sort="Scherag, Andre" uniqKey="Scherag A" first="Andre" last="Scherag">Andre Scherag</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</s1>
<s2>Essen</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>University of Duisburg-Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Centre National de la Recherche Scientifique (CNRS) 8199, Universite Lille Nord de France, Pasteur Institute</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M." last="Warrington">Nicole M. Warrington</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>School of Women's and Infants' Health, University of Western Australia, Perth</s1>
<s2>Western Australia</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hypponen">Elina Hypponen</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoist, Claus" sort="Hoist, Claus" uniqKey="Hoist C" first="Claus" last="Hoist">Claus Hoist</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Institute of Preventive Medicine, Copenhagen University Hospital</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Valcarcel, Beatriz" sort="Valcarcel, Beatriz" uniqKey="Valcarcel B" first="Beatriz" last="Valcarcel">Beatriz Valcarcel</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>48 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology I</s1>
<s2>Neuherberg</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Institute of Epidemiology I</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salem, Rany M" sort="Salem, Rany M" uniqKey="Salem R" first="Rany M." last="Salem">Rany M. Salem</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Division of Genetics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Division of Endocrinology, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Program in Genomics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Metabolism Program, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name>
</author>
<author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name>
</author>
<author><name sortKey="Sleiman, Patrick M A" sort="Sleiman, Patrick M A" uniqKey="Sleiman P" first="Patrick M. A." last="Sleiman">Patrick M. A. Sleiman</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jianhua Zhao" sort="Jianhua Zhao" uniqKey="Jianhua Zhao" last="Jianhua Zhao">JIANHUA ZHAO</name>
</author>
<author><name sortKey="Berkowitz, Robert I" sort="Berkowitz, Robert I" uniqKey="Berkowitz R" first="Robert I." last="Berkowitz">Robert I. Berkowitz</name>
</author>
<author><name sortKey="Vimaleswaran, Karani S" sort="Vimaleswaran, Karani S" uniqKey="Vimaleswaran K" first="Karani S." last="Vimaleswaran">Karani S. Vimaleswaran</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jarick, Ivonne" sort="Jarick, Ivonne" uniqKey="Jarick I" first="Ivonne" last="Jarick">Ivonne Jarick</name>
</author>
<author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>School of Women's and Infants' Health, University of Western Australia, Perth</s1>
<s2>Western Australia</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="St Pourcain, Beate" sort="St Pourcain, Beate" uniqKey="St Pourcain B" first="Beate" last="St Pourcain">Beate St Pourcain</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berry, Diane J" sort="Berry, Diane J" uniqKey="Berry D" first="Diane J." last="Berry">Diane J. Berry</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Pediatrics, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duijn, Cornelia M Van" sort="Duijn, Cornelia M Van" uniqKey="Duijn C" first="Cornelia M. Van" last="Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Valk, Ralf J P" sort="Van Der Valk, Ralf J P" uniqKey="Van Der Valk R" first="Ralf J. P." last="Van Der Valk">Ralf J. P. Van Der Valk</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Jongste, Johan C" sort="De Jongste, Johan C" uniqKey="De Jongste J" first="Johan C." last="De Jongste">Johan C. De Jongste</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name>
</author>
<author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name>
</author>
<author><name sortKey="Gauderman, W James" sort="Gauderman, W James" uniqKey="Gauderman W" first="W. James" last="Gauderman">W. James Gauderman</name>
</author>
<author><name sortKey="Hassanein, Mohamed T" sort="Hassanein, Mohamed T" uniqKey="Hassanein M" first="Mohamed T." last="Hassanein">Mohamed T. Hassanein</name>
</author>
<author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name>
</author>
<author><name sortKey="Boreham, Colin A G" sort="Boreham, Colin A G" uniqKey="Boreham C" first="Colin A. G." last="Boreham">Colin A. G. Boreham</name>
</author>
<author><name sortKey="Neville, Charlotte E" sort="Neville, Charlotte E" uniqKey="Neville C" first="Charlotte E." last="Neville">Charlotte E. Neville</name>
</author>
<author><name sortKey="Moreno, Luis A" sort="Moreno, Luis A" uniqKey="Moreno L" first="Luis A." last="Moreno">Luis A. Moreno</name>
</author>
<author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>48 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name>
</author>
<author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name>
</author>
<author><name sortKey="Mingyao Li" sort="Mingyao Li" uniqKey="Mingyao Li" last="Mingyao Li">MINGYAO LI</name>
</author>
<author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name>
</author>
<author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name>
</author>
<author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
</author>
<author><name sortKey="Dallongeville, Jean" sort="Dallongeville, Jean" uniqKey="Dallongeville J" first="Jean" last="Dallongeville">Jean Dallongeville</name>
</author>
<author><name sortKey="Das, Shikta" sort="Das, Shikta" uniqKey="Das S" first="Shikta" last="Das">Shikta Das</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>48 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name>
</author>
<author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name>
</author>
<author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name>
</author>
<author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L." last="Buxton">Jessica L. Buxton</name>
</author>
<author><name sortKey="Blakemore, Alexandra I F" sort="Blakemore, Alexandra I F" uniqKey="Blakemore A" first="Alexandra I. F." last="Blakemore">Alexandra I. F. Blakemore</name>
</author>
<author><name sortKey="Bustamante, Mariona" sort="Bustamante, Mariona" uniqKey="Bustamante M" first="Mariona" last="Bustamante">Mariona Bustamante</name>
</author>
<author><name sortKey="Guxens, Monica" sort="Guxens, Monica" uniqKey="Guxens M" first="Monica" last="Guxens">Monica Guxens</name>
</author>
<author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Division of Genetics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Division of Endocrinology, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Program in Genomics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Metabolism Program, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gillman, Matthew W" sort="Gillman, Matthew W" uniqKey="Gillman M" first="Matthew W." last="Gillman">Matthew W. Gillman</name>
</author>
<author><name sortKey="Kreiner Moller, Eskil" sort="Kreiner Moller, Eskil" uniqKey="Kreiner Moller E" first="Eskil" last="Kreiner-Moller">Eskil Kreiner-Moller</name>
</author>
<author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name>
</author>
</analytic>
<series><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term>
<term>Identification</term>
<term>Locus</term>
<term>Metaanalysis</term>
<term>Nutritional status</term>
<term>Obesity</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Association</term>
<term>Métaanalyse</term>
<term>Identification</term>
<term>Locus</term>
<term>Etat nutritionnel</term>
<term>Obésité</term>
<term>Echelle du génome</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10-<sup>6</sup>
 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10-<sup>9</sup>
; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10<sup>-9</sup>
; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI<sup>1</sup>
.</div>
</front>
</TEI>
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<li>Australie</li>
<li>Danemark</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Hauts-de-France</li>
<li>Hollande-Méridionale</li>
<li>Hovedstaden</li>
<li>Massachusetts</li>
<li>Nord-Pas-de-Calais</li>
<li>Pennsylvanie</li>
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<li>Lille</li>
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<name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L." last="Buxton">Jessica L. Buxton</name>
<name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name>
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<name sortKey="Jianhua Zhao" sort="Jianhua Zhao" uniqKey="Jianhua Zhao" last="Jianhua Zhao">JIANHUA ZHAO</name>
<name sortKey="Kreiner Moller, Eskil" sort="Kreiner Moller, Eskil" uniqKey="Kreiner Moller E" first="Eskil" last="Kreiner-Moller">Eskil Kreiner-Moller</name>
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<name sortKey="Salem, Rany M" sort="Salem, Rany M" uniqKey="Salem R" first="Rany M." last="Salem">Rany M. Salem</name>
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A genome-wide association meta-analysis identifies new childhood obesity loci

A genome-wide association meta-analysis identifies new childhood obesity loci

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